Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.24.05 | Thyroid–genetics | ECE2015

Telomerase reverse transcriptase promoter mutation analysis on thyroid core needle biopsy

Callea Marcella , Crescenzi Anna , Trimboli Pierpaolo , Modica Davide Cicciarella , Taffon Chiara , Guidobaldi Leo , Taccogna Silvia , Rainer Alberto , Trombetta Marcella , Papini Enrico , Zelano Giovanni

Introduction: Among molecular markers proposed to improve diagnosis of thyroid nodules, mutations in telomerase reverse transcriptase (TERT) promoter have been correlated to malignant tumors with highest recurrence and decreased patientÂ’s survival. This suggests an important role of TERT mutational analysis in the clinical diagnosis and management of thyroid cancer patients. In this study, we investigate the potential use of core needle biopsy (CNB) for the preoperative a...